[38][39] Distribution and storage of the vaccine is a logistics challenge because it needs to be stored at extremely low temperatures. Pfizer Inc., är ett amerikanskt multinationellt läkemedelsföretag med huvudkontor i New York som genom köpet av Pharmacia år 2003 blev världens största företag inom läkemedelsindustrin. [18][204][205][206] By mid-December 2020, Pfizer had agreements to supply 300 million doses to the European Union,[207] 120 million doses to Japan,[208] 40 million doses (10 million before 2021) to the United Kingdom,[58] 20 million doses to Canada,[209] an unspecified number of doses to Singapore,[210] and 34.4 million doses to Mexico. Die Firmenzentrale wurde 2008 von Karlsruhe nach Berlin verlegt. Pfizer did enter into an agreement with the US for the eventual distribution of the vaccine, as with other countries. The site will be the third BioNTech facility in Europe which currently produces the vaccine, while Pfizer operates at least four production sites in the United States and Europe. [56], The ongoing Phase III trial, which is scheduled to run from 2020 to 2022, is designed to assess the ability of BNT162b2 to prevent severe infection, as well as the duration of immune effect. [161] Following the EUA issuance, BioNTech and Pfizer are expected to continue the Phase III clinical trial to finalize safety and efficacy data, leading to application for licensure (approval) of the vaccine in the United States. [64], In addition to the mRNA molecule, the vaccine contains the following inactive ingredients (excipients):[66][67][9], The first four of these are lipids. [215]In Response South Africa has secured 20 Million doses expected to be delivered in consignments after March[216], BNT162b2 was the code name during development and testing,[19][217] tozinameran is the proposed international nonproprietary name (pINN),[218] and Comirnaty is the brand name. The bags are placed on special racks on trucks which take them to the next plant. It is an RNA vaccine made of nucleoside-modified mRNA which is meant to create spike protein of SARS-CoV-2. It was founded in 1849 in New York City. It won't be easy", "Recommendation for an Emergency Use Listing of Tozinameran (Covid-19 Mrna Vaccine (Nucleoside Modified)) Submitted by Biontech Manufacturing Gmbh", "Australian Product Information – Comirnaty (BNT162b2 [mRNA]) COVID-19 Vaccine", "Coronavirus (COVID-19) Update: FDA Allows More Flexible Storage, Transportation Conditions for Pfizer-BioNTech COVID-19 Vaccine", "Pfizer and BioNTech Submit COVID-19 Vaccine Stability Data at Standard Freezer Temperature to the U.S. FDA", "Pfizer and BioNTech's vaccine poses global logistics challenge", "Daunting task of distribution exposed as it emerges some vaccines must be 'deep frozen' at −70C", "How China's COVID-19 could fill the gaps left by Pfizer, Moderna, AstraZeneca", "Pfizer's Vaccine Is Out of the Question as Indonesia Lacks Refrigerators: State Pharma Boss", "U.S. to pay Pfizer, BioNTech $1.95 bln for millions of COVID-19 vaccine doses", "U.S. Government Engages Pfizer to Produce Millions of Doses of COVID-19 Vaccine", "So is Pfizer part of Operation Warp Speed or not? The production of the vaccine was followed by clinical trials, the success of which was a prerequisite for the commencement of marketing. Mikael Dolsten is Pres:Worldwide Research & Dev/Chief Scientific Ofcr at Pfizer Inc. See Mikael Dolsten's compensation, career history, education, & memberships. The Phase II portion of the study will include approximately 350 pregnant women randomized 1:1 to receive BNT162b2 or placebo at 27 to 34 weeks' gestation. One of the world's largest pharmaceutical companies, it is ranked 64 on the 2020 Fortune 500 list of the largest United States corporations by total revenue. For all markets, this stage is conducted in the United States,[180] at a small Pfizer pilot plant in Chesterfield, Missouri[181] (near St. Louis). [177][178][179] On 12 December, the Canadian regulator followed suit, noting that: "Both individuals in the U.K. had a history of severe allergic reactions and carried adrenaline auto injectors. This is what happened to Dr. Mike Yeadon, a 17-year Pfizer veteran at Pfizer’s R&D unit in Sandwich, England. Pfizer acquired an 80-acre site on the outskirts of Sandwich in 1954 to enable the expansion of its Kent-based activities. From scientific discovery to breakthrough products to our essential partnerships around the world, we’re committed to … [67], Severe allergic reaction has been observed in approximately 11 cases per million doses of vaccine administered. A Pfizer Inc. multinacionális gyógyszergyár, amelynek székhelye New Yorkban, az Amerikai Egyesült Államok területén található. [60], The BioNTech technology for the BNT162b2 vaccine is based on use of nucleoside-modified mRNA (modRNA) which encodes part of the spike protein found on the surface of the SARS-CoV-2 coronavirus (COVID‑19), triggering an immune response against infection by the virus protein. The company is responsible for the first COVID-19 vaccination. [62], The modRNA sequence of the vaccine is 4,284 nucleotides long. [2] Deutsche Niederlassungen befinden sich in Karlsruhe und Freiburg. This page was last changed on 15 February 2021, at 18:49. The Pfizer–BioNTech COVID‑19 vaccine (pINN: tozinameran), sold under the brand name Comirnaty,[15] is an mRNA based COVID-19 vaccine. [214], In January 2021, Pfizer and BioNTech offered to supply 50 million doses of COVID‑19 vaccine for health workers across Africa between March and the end of 2021, at a discounted price of US$10 per dose. [27][28] Monitoring of the primary outcomes from the trials will continue until August 2021, while monitoring of the secondary outcomes will continue until January 2023. [203], In July 2020, the vaccine development program Operation Warp Speed placed an advance order of US$1.95 billion with Pfizer to manufacture 100 million doses of a COVID‑19 vaccine for use in the United States if the vaccine was shown to be safe and effective. When used before surgery, it reduces pain but results in greater sedation and visual disturbances. [182] Croda International subsidiary Avanti Polar Lipids is providing the requisite lipids. [49], In June 2020, BioNTech received €100 million (US$119 million) in financing from the European Commission and European Investment Bank. To satisfy regulations then in place in the United Kingdom on the importation of medicines, Pfizer established a compounding operation in Folkestone, Kent, in the Autumn of 1952. [40], Before COVID-19 vaccines, a vaccine for an infectious disease had never before been produced in less than several years, and no vaccine existed for preventing a coronavirus infection in humans. In Deutschland beschäftigt Pfizer rund 2500 Mitarbeiter. [28] In a report published on 4 March 2021 it concluded that "the benefits of Comirnaty in preventing COVID-19 continue to outweigh any risks, and there are no recommended changes regarding the use of this vaccine. [20], It is both the first COVID-19 vaccine to be authorized by a stringent regulatory authority for emergency use[29][30] and the first cleared for regular use. [20][61][53] Prior to choosing BNT162b2, BioNTech and Pfizer had conducted Phase I trials on BNT162b1 in Germany and the United States, while Fosun performed a Phase I trial in China. [67] Fever is more common after the second dose. This was 100% of all the recorded Pfizer's in the USA. [63] The sequence contains no uridine residues; they are replaced by 1-methyl-3'-pseudouridylyl. We strive to set the standard for quality, safety and value in the discovery, development and manufacture of health care products, including innovative medicines and vaccines. This stage involves combining the mRNA with lipid nanoparticles, then filling vials, boxing vials, and freezing them. For other vaccination topics, see, A vial of the Pfizer–BioNTech COVID‑19 vaccine, US authorization also includes the three sovereign nations in the, Chinese Center for Disease Control and Prevention, COVID-19 vaccine § Clinical trials started in 2020, National Institute of Allergy and Infectious Diseases, 1,2-distearoyl-sn-glycero-3-phosphocholine, Medicines and Healthcare products Regulatory Agency, Centers for Disease Control and Prevention, Advisory Committee on Immunization Practices, Swiss Agency for Therapeutic Products (Swissmedic), Committee for Medicinal Products for Human Use, "Swissmedic grants authorisation for the first COVID-19 vaccine in Switzerland", "Comirnaty (BNT162b2 [mRNA]) COVID‑19 Vaccine Product Information", Australian Public Assessment Report for BNT162b2 (mRNA), "Regulatory Decision Summary – Pfizer-BioNTech COVID-19 Vaccine", "Pfizer-BioNTech COVID-19 Vaccine (tozinameran)", "Information for Healthcare Professionals on Pfizer/BioNTech COVID-19 vaccine", "Conditions of Authorisation for Pfizer/BioNTech COVID-19 vaccine", "FDA Takes Key Action in Fight Against COVID-19 By Issuing Emergency Use Authorization for First COVID-19 Vaccine", "Pfizer-BioNTech COVID-19 Vaccine- rna ingredient bnt-162b2 injection, suspension", Pfizer-BioNTech COVID-19 Vaccine Emergency Use Authorization Review Memorandum, "Pfizer-BioNTech COVID-19 Vaccine Standing Orders for Administering Vaccine to Persons 16 Years of Age and Older", "mRNA vaccines to address the COVID-19 pandemic", "What you need to know about BioNTech – the European company behind Pfizer's Covid-19 vaccine", "Pfizer's early data shows vaccine is more than 90% effective", "Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates", "Pfizer says experimental COVID-19 vaccine is more than 90% effective", "Covid-19 vaccine from Pfizer and BioNTech is strongly effective, early data from large trial indicate", "Update on our COVID-19 vaccine development program with BNT162b2", "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "Questions and Answers About Pfizer-BioNTech COVID-19 Vaccine", "UK medicines regulator gives approval for first UK COVID-19 vaccine", "UK approves Pfizer/BioNTech Covid vaccine for rollout next week", "EMA recommends first COVID-19 vaccine for authorisation in the EU", "Bahrain becomes second country to approve Pfizer COVID-19 vaccine", "Coronavirus: Saudi Arabia approves Pfizer COVID-19 vaccine for use", "Mexico approves emergency use of Pfizer's COVID-19 vaccine", "F.D.A. The license to distribute and manufacture in China was purchased by Fosun, alongside its investment in BioNTech. The STANDS4 Network ... Wikipedia (0.00 / 0 votes) ... English (English) Word of the Day [201][202], Pfizer indicated in its 9 November press release that 50 million doses could be available by the end of 2020, with about 1.3 billion doses provided globally by 2021. [2][171][172] The recommendation was accepted by the European Commission the same day. [20] It is a "randomized, placebo-controlled, observer-blind, dose-finding, vaccine candidate-selection, and efficacy study in healthy individuals". [195][196] In February 2021, the U.S. Food and Drug Administration (FDA) updated the emergency use authorization (EUA) to permit undiluted frozen vials of the vaccine to be transported and stored at between −25 and −15 °C (−13 and 5 °F) for up to two weeks before use. History. [2] In Österreich gliedert sich das Unternehmen in zwei Gesellschaften. [1][168] On 23 December, a Lucerne resident, a 90-year-old woman, became the first person to receive the vaccine in Switzerland. [180] Therefore, all doses administered in the Americas outside of the United States have required at least two transatlantic flights (one to take DNA to Europe and one to bring back finished vaccine vials). În 2012, a fost una dintre cele mai mari companii farmaceutice din lume și s-a clasat pe locul 57 pe lista Fortune 500 din 2018 a celor mai mari corporații din SUA după venituri totale. [182], The third stage is being conducted at Pfizer plants in Portage, Michigan[184] (near Kalamazoo) in the United States, and Puurs in Belgium. [22] In February 2021, BioNTech announced it would increase production by more than 50% to manufacture two billion doses in 2021. [23] Several variants of the vaccine were created in their laboratories in Mainz, and 20 of those were presented to experts of the Paul-Ehrlich-Institute in Langen. ", "From science to syringe: COVID-19 vaccines are miracles of science and supply chains", "Pfizer's Chesterfield workforce playing a key role in coronavirus vaccine development", "A vial, a vaccine and hopes for slowing a pandemic — how a shot comes to be", "Historic journey: Pfizer prepares to deliver 6.4 million doses of COVID-19 vaccines", "Pfizer, Moderna ready vaccine manufacturing networks", "Pfizer expects to cut COVID-19 vaccine production time by close to 50% as production ramps up, efficiencies increase", "BioNTech to Acquire GMP Manufacturing Site to Expand COVID-19 Vaccine Production Capacity in First Half 2021", "Pfizer-BioNTech COVID-19 Vaccine Frequently Asked Questions", "Extra dose from vials of Comirnaty COVID-19 vaccine", "AIFA, possibile ottenere almeno 6 dosi da ogni flaconcino del vaccino BioNTech/Pfizer", "Biden wants to squeeze an extra shot of vaccine out of every Pfizer vial. [182], The second stage is being conducted at a Pfizer plant in Andover, Massachusetts[183] in the United States, and at BioNTech's plants in Germany. [180], The Pfizer plant in Puurs is responsible for all vials for destinations outside the United States. Use census records and voter lists to see where families with the Pfizer surname lived. [212] The Hong Kong government said it would receive its first batch of one million doses by the first quarter of 2021. [164][165], On 16 February 2021, the South African Health Products Regulatory Authority (SAHPRA) in South Africa issues Section 21, Emergency Use Approval for the vaccine. [175][176] According to a report by the US Centers for Disease Control and Prevention 71% of those allergic reactions happened within 15 minutes of vaccination and mostly (81%) among people with a documented history of allergies or allergic reactions. Some older people living with cancer aim for remission but lack… Both doses should be Pfizer-BioNTech COVID-19 Vaccine. [187], The vaccine is being delivered in vials that, once diluted, contain 2.25 ml of vaccine (0.45 ml frozen plus 1.8ml diluent). Other resolutions: 320 × 131 pixels | 640 × 262 pixels | 1,024 × 419 pixels | 1,280 × 524 pixels | 1,000 × 409 pixels. At Pfizer, we innovate every day to make the world a healthier place. [180] Once the mRNA has been created and purified, it is frozen in plastic bags about the size of a large shopping bag, of which each can hold up to 5 to 10 million doses. [169] This marked the beginning of mass vaccination in continental Europe. [20] The early-stage research determined the safety and dose level for two vaccine candidates, with the trial expanding during mid-2020 to assess efficacy and safety of BNT162b2 in greater numbers of participants, reaching tens of thousands of people receiving test vaccinations in multiple countries in collaboration with Pfizer and Fosun. Other resolutions: 320 × 192 pixels | 640 × 383 pixels | 1,024 × 613 pixels | 1,280 × 767 pixels | 1,000 × 599 pixels. [2] Företaget har 80 000 medarbetare och finns i fler än 150 länder. [52], Phase I / II Trials were started in Germany on 23 April 2020, and in the U.S. on 4 May 2020, with four vaccine candidates entering clinical testing. [67][191][192][189] In the United States, vials will be counted as five doses when accompanied by regular syringes and as six doses when accompanied by low dead space syringes. Yrityksen pääkonttori sijaitsee New Yorkissa.Yrityksellä oli noin 90 000 työntekijää vuonna 2018, ja liikevaihdoltaan se on Fortune 500-listan mukaan maailman 61:nneksi suurin yritys. The German company BioNTech is the initial developer of the vaccine, and partnered with Chinese company Fosun[16] as well as American company Pfizer for support with the clinical trials, logistics and manufacturing.[17][18]. There, they produced an antiparasitic called santonin. The most Pfizer families were found in the USA in 1880. Yes and no", "EU agrees to buy 300 million doses of the Pfizer/BioNTech Covid-19 vaccine", "Japan and Pfizer reach COVID-19 vaccine deal to treat 60 million people", "Trudeau says promising new Pfizer vaccine could be 'light at the end of the tunnel, "Pfizer and BioNTech to Supply Singapore with their BNT162b2 mRNA-based Vaccine Candidate to Combat COVID-19", "233. [137], After the United Kingdom, the following countries expedited processes to approve the Pfizer–BioNTech COVID‑19 vaccine for use: Argentina,[138] Australia,[139] Bahrain,[140] Canada,[8][141] Chile,[142] Costa Rica,[143] Ecuador,[142] Hong Kong,[144] Iraq,[145] Israel,[146] Jordan,[147] Kuwait,[148] Malaysia,[149] Mexico,[150] Oman,[151] Panama,[108] the Philippines,[152] Qatar,[153] Saudi Arabia,[35][154] Singapore,[155][156] South Korea,[157][158] the United Arab Emirates,[159] and the United States. [180] The DNA is used as a template to build the desired mRNA strands,[182] which takes about four days. [20] For approval in the EU, an overall vaccine efficacy of 95% was confirmed by the EMA. Pfizer, la compagnie pharmaceutique mondialement reconnue. [24][25] Reports of serious side effects, such as allergic reactions, have been very rare,[a] and no long-term complications have been reported. Information and translations of Pfizer in the most comprehensive dictionary definitions resource on the web. [22] During clinical trials, the side effects deemed very common[a] are (in order of frequency): pain and swelling at the injection site, tiredness, headache, muscle aches, chills, joint pain, and fever. [182] At this stage, it takes only four days to go from mRNA and lipids to finished vials, but each lot must then spend several weeks in deep-freeze storage while undergoing verification against 40 quality-control measures. [23], Preliminary results from Phase I–II clinical trials on BNT162b2, published in October 2020, indicated potential for its efficacy and safety. 70% had been to people aged 80 or over. [20][21][22] It is one of the two RNA vaccines deployed against COVID‑19 in 2020, the other being the Moderna COVID‑19 vaccine. "[219][220], The vaccine also has the common name "COVID‑19 mRNA vaccine (nucleoside-modified)"[2] and may be distributed in packaging with the name Pfizer–BioNTech COVID‑19 Vaccine. Its use in epilepsy is as an add-on therapy for partial seizures. "Project Lightspeed", the project to develop a novel mRNA technology for a COVID-19 vaccine, began in mid-January 2020 just days after the SARS-Cov-2 genetic sequence was first made public. Firma secretario de Salud convenio con Pfizer para fabricación y suministro de vacuna COVID-19", "Fosun Pharma to supply Covid-19 vaccine to Hong Kong, Macau once approved", "Hong Kong buys 15 million Covid-19 vaccine doses from Sinovac, Pfizer", "BioNTech and Fosun Pharma to Supply China with mRNA-based COVID-19 Vaccine", "Pfizer Has Offered South Africa Discounted Covid-19 Vaccines", "SA has secured more than 40 million Covid-19 vaccine doses - Ramaphosa", "International Nonproprietary Names for Pharmaceutical Substances (INN). [4][5] It was founded in 1849 in New York City. Főbb termékei. The German company BioNTech is the initial developer of the vaccine, and partnered with American company Pfizer for support with the clinical trials, logistics and manufacturing. Pfizer(/ ˈ f aɪ z ər /) is an American pharmaceutical corporation. History 1952–2000. : Pfizer, the world's largest research-based pharmaceutical company. [187] Once fully operational, the facility would produce up to 750 million doses per year, or over 60 million doses per month. [130] It was the first COVID‑19 vaccine to be approved for national use after undergoing large scale trials,[131] and the first mRNA vaccine to be authorized for use in humans. [29][132] The United Kingdom thus became the first Western country to approve a COVID‑19 vaccine for national use,[133] although the decision to fast-track the vaccine was criticised by some experts. [4 História. Pfizer and BioNTech announced on 18 February 2021 that the first participants received their first dose in this trial. One of the world's largest pharmaceutical companies, it is ranked 64 on the 2020 Fortune 500 list of the largest United States corporations by total revenue. Pfizer's history starts in 1849 with founder Pfizer & Erhart cousins who started their NY office, laboratory, factory, and warehouse. "[3], "Pfizer vaccine" and "BioNTech vaccine" redirect here. [22][57][58], The vaccine's ability to prevent severe infection in children, pregnant women, or immunocompromised people is unknown, as is the duration of the immune effect it confers. The first stage involves the molecular cloning of DNA plasmids that code for the spike protein by infusing them into Escherichia coli bacteria. 辉瑞公司（英語： Pfizer, Inc. ， / ˈ f aɪ z ər / ），是一家总部位于美国 纽约的跨国制药、生物技術公司，研发总部位于康涅狄格州的格罗顿市。 根据收入排名，辉瑞是全球最大的制药公司。 輝瑞公司的股票於2004年4月8日成為道瓊斯工業指數的成份股。
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